Antioxidant Approach to the Therapy of Chronic Liver Diseases. Oxidative stress was first reported in the 1. Several liver diseases including chronic hepatitis, alcoholic- and non- alcoholic fatty liver disease, liver fibrosis/cirrhosis, and cancer are associated with harmful oxidative actions. Therefore, antioxidant therapy constitutes a promising approach to the treatment of such liver diseases. Many reports using animal models, and from human trials, have revealed the beneficial effects of antioxidants given as sole or adjuvant therapies. This chapter gives a detailed classification of antioxidants and the applications thereof, while also canvassing limitations, in the treatment of chronic liver diseases. Keywords. Antioxidants Antioxidant therapy Intracellular antioxidants Extracellular antioxidants Chronic liver diseases Oxidative stress Nitric oxide Cytoglobin Vitamin E and C N- acetylcysteine.
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